Mechanism of Kir6.2 channel inhibition by sulfhydryl modification: pore block or allosteric gating?
نویسندگان
چکیده
منابع مشابه
Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification
ATP-sensitive potassium (KATP) channels are reversibly inhibited by intracellular ATP. Agents that interact with sulfhydryl moieties produce an irreversible inhibition of KATP channel activity when applied to the intracellular membrane surface. ATP appears to protect against this effect, suggesting that the cysteine residue with which thiol reagents interact may either lie within the ATP-bindin...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2002
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2001.013366